Jason A. Berberich, Ph.D.

Portrait of Dr. Jason Berberich

Associate Professor

64P Engineering Building

Research Interests

  • Biocatalysis and biotransformations
  • Stabilization and immobilization of biocatalysts
  • Application of biocatalysts in renewable energy, green chemistry, and chemical and biological weapons defense
  • Medical diagnostics and therapeutics


  • Ph.D., Chemical Engineering
    University of Kentucky
  • B.S., Chemical Engineering,
    University of Kentucky

Academic Appointments

  • Assistant Professor of Chemical and Paper Engineering, Miami University, 2012–present
  • Institute Scientist, McGowan Institute of Regenerative Medicine, Univ. of Pittsburgh, 2002–2003
  • Research Associate, Department of Chemical and Petroleum Engineering, Univ. of Pittsburgh, 2001–2002

Research Projects

  • Enzymes and Proteins for sensor development

Professional Experience

  • Manager, Enzyme Research, FLIR Systems (formerly ICx Technologies), Pittsburgh, PA, 2011–2012
  • Director of Development, ICx Technologies, Pittsburgh, PA, 2008–2011
  • Senior Research Engineering, ICx Technologies (formerly Agentase), Pittsburgh, PA, 2004–May 2008


  • Co-inventor and co-author of the US patent entitled "Seafood Spoilage Indicator," 8,017,352, issued September 2011

Principal Publications

  • Plaks, JG, Falatach, R, Kastantin, M,  Berberich, JA, Kaar, JL (2015). Multisite Clickable Modification of Proteins Using Lipoic Acid Ligase. BIOCONJUGATE CHEMISTRY, 26 (6), pp. 1104-1112. 
  • Fitzgerald, MM, Bootsma, K,  Berberich, JA, Sparks, JL (2015). Tunable Stress Relaxation Behavior of an Alginate-Polyacrylamide Hydrogel: Comparison with Muscle Tissue. BIOMACROMOLECULES, 16(5), pp. 1497-1505. 
  • Falatach, R, McGlone, C, Al-Abdul-Wahid, MS, Averick, S, Page, RC, Berberich, JA, Konkolewicz, D (2015). The best of both worlds: active enzymes by grafting-to followed by grafting-from a protein. CHEMICAL COMMUNICATIONS, 51(25), pp. 5343-5346.  J.A. Berberich, M. Erbeldinger, J. Sinclair and J.P. Walker. Immobilization – Biological. In Encyclopedia of Catalysis, 2010.
  • J.A. Berberich. Stress of Chemical Warfare. In The Encyclopedia of Stress. 2nd Edition, 2007.
  • G.D. Bothun, Y.W. Kho, J.A. Berberich, J. Shofner, T. Robertson, K.J. Tatum, and B.L. Knutson. Surface Activity of Aqueous Lysozyme and Dipalmitoyl Phosphatidylcholine Vesicles at Compressed and Supercritical Fluid Interfaces, Journal of Physical Chemistry B, v109, p24495-24501, 2005.
  • J.A. Berberich, L.W. Yang, J. Madura, I. Bahar, and A.J. Russell. A Stable Three- Enzyme Creatinine Biosensor. 1. Impact of Structure, Function and Environment on PEGylated and Immobilized Sarcosine Oxidase, Acta Biomaterialia, v1, p173-181, 2005.
  • J.A. Berberich, L.W. Yang, I. Bahar, and A.J. Russell. A Stable Three-Enzyme Creatinine Biosensor. 2. Analysis of the Impact of Silver Ions on Creatine Amidinohydrolase, Acta Biomaterialia, v1, p183-191, 2005.
  • J.A. Berberich, A. Chan, and M. Boden, and A.J. Russell. A Stable Three-Enzyme Creatinine Biosensor. 3. Immobilization of Creatinine Amidohydrolase and Sensor Development, Acta Biomaterialia, v1, p193-199, 2005.
  • G.D. Bothun, B.L. Knutson, J.A. Berberich, H.J. Strobel, and S.E Nokes. Metabolic selectivity and growth of Clostridium thermocellum in Continuous Culture under Elevated Hydrostatic Pressure, Applied Microbiology and Biotechnology, v65, p149- 157, 2004.
  • A.J. Russell, J.L. Kaar, and J.A. Berberich. Using Biotechnology to Detect and Counteract Chemical Weapons, The Bridge (A publication of the National Academy of Engineering), p19-24, Winter 2003.
  • J.A. Berberich, G.F. Drevon, R. Koepsel, and A.J. Russell. Biomaterials For Mediation of Chemical and Biological Warfare Agents, Annual Reviews in Biomedical Engineering, v5, p1-27, 2003.
  • J.A. Berberich, J.L. Kaar, and A.J. Russell. Use of Salt Hydrate Pairs to Control Water Activity for Enzyme Catalysis in Ionic Liquids, Biotechnology Progress. v10. p1029-1032, 2003.
  • J.L Kaar, A.M. Jesionowsk, J.A. Berberich, R. Moulton, and A.J. Russell. The Relationship Between Ionic Liquid Physical Properties and Enzyme Activity and Stability, Journal of the American Chemical Society, v125, p4125-4131, 2003.
  • J.A. Luckman, J.A. Berberich, D.C. Conrad, and B.L. Knutson. Manipulation of the Liquid-Liquid Equilibrium of Vertrel-XF + Hydrocarbon Systems with the Addition of a Third Component, Industrial and Engineering Chemistry Research, v41, p2792- 2797, 2002.
  • J.A. Berberich, B.L. Knutson, H.J. Strobel, S. Tarhan, S.E. Nokes, and K. A. Dawson. Product Selectivity Shifts in Clostridium thermocellum in the Presence of Compressed Solvents, Industrial and Engineering Chemistry Research, v39, p4500- 4505, December 2000.
  • J.A. Berberich, B.L. Knutson, H.J. Strobel, S. Tarhan, S.E. Nokes, and K. A. Dawson. Toxicity Effects of Compressed and Supercritical Solvents on Microbial Metabolism, Biotechnology and Bioengineering, v70, p491-497, December 2000.
  • B.L. Knutson, H.J. Strobel, S.E. Nokes, K.A. Dawson, J.A. Berberich and C.R. Jones. Effect of Pressurized Solvents on Ethanol Production by the Thermophilic Bacterium Clostridium thermocellum, Journal of Supercritical Fluids, v6, p149-156, November 1999.