Kang Kug (Paul) Lee, Ph.D.

Dr. Kang Kug (Paul) Lee

Visiting Assistant Professor

103 Benton Hall
(513) 529-3695
leek11
http://www.iNNOMeDevices.com

Research Interests

  • Design & manufacturing of microfluidic lab-on-a-chip platforms
  • 3D printed plasma isolation devices for point-of-care blood diagnostic innovations
  • Organoids/tissue/cells-on-a-chip
  • Biomedical micro-electro-mechanical systems (BioMEMS)

Education

  • Ph.D., Electrical Engineering and Computing Systems
    University of Cincinnati
    2013
  • M.S., Mechanical and Aerospace Engineering
    The Ohio State University
    2005
  • M.S., Metallurgy and Materials Engineering
    Hanyang University, South Korea
    2000
  • B.S., Metallurgy and Materials Engineering
    Hanyang University, South Korea
    1992

Professional Experience

  • 2019-present: Founder & CEO, iNNO MeDevice, Inc., Cincinnati, OH.
  • 2015-2018: Research Scientist for College of Medicine, Pharmacology and Systems Physiology, UC, Cincinnati, OH.
  • 2014-2015: Laboratory Research Assistant at Superior Talent Resources Inc., Affiliate for College of Medicine, Molecular and Cellular Physiology, UC, Cincinnati, OH.
  • 2006-2013: Graduate Research Assistant, Electrical Engineering & Computing Systems, UC, Cincinnati, OH.
  • 2006: Research Engineer, Biomedical Engineering, Ohio State University, Columbus, OH.
  • 2003-2005: Graduate Research Assistant, Mechanical and Aerospace Engineering, Ohio State University, Columbus, OH.

Honors and Fellowships

  • Presenting Student Author Travel Grant, Hilton Head 2012 Workshop, Transducer Research Foundation, San Diego CA. — 2012
  • University Graduate Scholarship, Electrical Engineering and Computing Systems, UC, Cincinnati OH. — 2006-2013
  • Engineering Research Fellowship, The Ohio State University, Columbus OH. — 2003-2005
  • Graduate Research Assistant, Hanyang University, South Korea. — 1998-2000
  • National Research Laboratory Graduate Fellowship Award, Hanyang University, South Korea. — 1998-2000

Professional Memberships, Certificates, and Scholar Activities

  • Present Journal Referee, review more than 50 articles for Lab on a Chip, Nanoscale, Journal of Materials Chemistry, ACS Applied Materials & Interfaces, Sensors & Actuators B, RSC Advances, Analyst, Talanta, Journal of MEMS, Biomicrofluidics, Fuel Cells, and RSC Analytical Methods. — 2013 - present
  • Present Member of Korean-American Scientists and Engineers Association (KSEA) — 2012
  • Certificate for Micro/Nano Microfluidics Biochip Fabrication, UC, Cincinnati OH — 2007
  • Certificate for Semiconductor Processing, Inter-university Semiconductor Research Center, Seoul, South Korea — 1999
  • Member of Materials Research Society & Korean Materials Research Society — 1999-2000

Funding

  • National Science Foundation (NSF) Small Business Innovation Research (SBIR) (Dr. Kang Kug Lee, Sole PI) 2019
    “Membraneless, low-cost, rapid, and portable plasma isolation device ”
    Role: Principal Investigator; Status: pending
  • University Research Council (URC) University of Cincinnati (Dr. Kang Kug Lee, Sole PI) 2008
    “A resorbable polymeric microchip as controlled-release implantable drug delivery devices ”
    Role: Principal Investigator; Status: funded

Research Supports

  • National Institutes of Health (NIH) 1U19AI116491 Dr. Christian I. Hong (Project III Co-Investigator)
    2015 – 2020
    “Colonoids and gastroids as 4D models of GI infection (Project III) ”in Project “Human gastrointestinal organoids as models of enteric disease ”(PIs: Drs. Alison Weiss & James Wells)
    Role: Research Scientist
  • Defense Advanced Research Projects Agency (DARPA) D12AP00005 Dr. Christian I. Hong (PI)
    2012 – 2015
    “Uncovering general principles of network dynamics of circadian rhythms, cell cycle, DNA damage response and metabolism as interconnected modules”
    Role: Research Assistant
  • Department of Defense (DoD) PT090526P4 Drs. Chunyan Li & Chong H. Ahn
    2010 – 2015
    “Novel smart catheter for multimodal monitoring of the head-injured warrior ”
    Role: Graduate Research Assistant
  • National Institute of Health (NIH) 5R01ES015446 Drs. Paul L. Bishop (PI) & Chong H. Ahn
    2006 – 2009
    “A point detection disposable lab-on-a-chip with built-in mercury precursor electrodes for heavy metal detection ”
    Role: Graduate Research Assistant
  • National Science Foundation (NSF) ECS – 0301056 Drs. Derek Hansford (PI) & Bharat Bhushan
    2004 – 2005
    “Development of vapor phase deposited fluorosilane films for biomedical nanodevices”
    Role: Graduate Research Assistant

Teaching and Mentoring Experience

  • Research advisor
    Mentored undergraduate, graduate students and postdocs for live imagining platform with gastrointestinal organoids & Neurospora crassa
    UC medical school & Cincinnati Children’s Hospital.
    2015-2018
  • Research advisor
    Mentored undergraduate and graduate students for surface modification with spray layer- by-layer nanoassembly method for biomedical applications
    Electrical Engineering & Computing Systems, UC.
    2012-2013
  • Teaching Assistant
    Silicon Semiconductor Microfabrication Lab for MEMS (ECE641)
    Electrical Engineering & Computing Systems, UC
    Winter 2008
  • Research advisor
    Mentored undergraduate and graduate students for performing surface modification of the fluorocarbon thin films to prevent the stiction problem in micromirrors by a vapor phase deposition system
    Metallurgy & Materials Engineering, Hanyang University (South Korea)
    1999-2000
  • Grader
    Semiconductor Processing
    Metallurgy & Materials Engineering, Hanyang University (South Korea)
    1999-2000

Publications

Peer-reviewed Journal Articles

  1. Kang Kug Lee (Corresponding author), Myoung-Ok Kim, Seokheun Choi. A whole blood sample-to-answer polymer lab-on-a-chip with superhydrophilic surface toward point-of-care technology. J Pharm Biomed Anal, vol. 162, pp. 28 – 33, 2019.
  2. Kang Kug Lee (Corresponding author), Heather A. McCauley, Taylor R. Broda, Matthew J. Kofron, James M. Wells, Christian I. Hong. Human stomach-on-a-chip with intraluminal flow and peristaltic-like motility. Lab Chip, vol. 18, pp. 3079 – 3085, 2018.
  3. Weiyang Yang, Kang Kug Lee, Seokheun Choi. A laminar-flow based microbial fuel cell array. Sens. Actuators B, vol. 243, pp. 292 – 297, 2017.
  4. Kang Kug Lee, Laszlo Labiscsak, Chong H. Ahn, Christian I. Hong. Spiral-based microfluidic device for long-term time course imaging of Neurospora crassa with single nucleus resolution. Fungal Genet. Biol. vol. 94, pp. 11 – 14, 2016.
  5. Kang Kug Lee (Corresponding author) and Chong H. Ahn. A new on-chip whole blood/plasma separator driven by asymmetric capillary forces. Lab Chip. vol. 13, pp. 3261 – 3267, 2013.
  6. Kang Kug Lee (Corresponding author) and Chong H. Ahn. Superhydrophilic multilayer silica nanoparticle networks on a polymer microchannel using a spray layer-by-layer nanoassembly method. ACS Appl. Mater. Interfaces. vol. 5(17), pp. 8523 – 8530, 2013.
  7. Kang Kug Lee, Chong H. Ahn, Christian I. Hong. Circadian rhythms in Neurospora Crassa on polydimethylsiloxane microfluidic device for real-time gas perturbations. Biomicrofluidics. vol. 7, pp. 044129 – 1 – 044129 – 7, 2013.
  8. Am Jang, Kang Kug Lee, Paul L. Bishop, Insu Kim, Chong H. Ahn. Development of polymer lab-on-a-chip (LOC) for oxidation-reduction potential (ORP) measurement. Water Sci. Technol. vol. 63, No. 10, pp. 2309 - 2315, 2011
  9. Am Jang, Zhiwei Zou, Kang Kug Lee, Chong H. Ahn, Paul L. Bishop. State-of-the-art lab chip sensors for environmental water monitoring. Meas. Sci. Technol. vol. 22, No. 032001, pp. 1 – 18, 2011.
  10. Am Jang, Zhiwei Zou, Kang Kug Lee, Chong H. Ahn, Paul L. Bishop. Potentiometric and voltammetric polymer lab chip sensors for determination of nitrate, pH and Cd(II) in water. Talanta. vol. 83(1), pp. 1 – 8, November, 2010.
  11. Bharat Bhushan, Derek Hansford, Kang Kug Lee. Surface modification of silicon and polydimethylsiloxane surfaces with vapor-phase-deposited ultrathin fluorosilane films for biomedical nanodevices. J. Vac. Sci. Technol., A. vol.24(4), Jul/Aug, pp.1197 – 1202, 2006.
  12. Kang Kug Lee, Bharat Bhushan, Derek Hansford. Nanotribological characterization of fluoropolymer thin films for biomedical micro/nanoelectromechanical system applications. J. Vac. Sci. Technol., A. vol. 23(4) Jul/Aug, pp. 804 – 810, 2005.
  13. Kang Kug Lee, Nam-Goo Cha, Joon-Sung Kim, Jin-Goo Park, Hyung-Jae Shin. Chemical, optical and tribological characterization of perfluoropolymer films as an anti-stiction layer in micro-mirror arrays. Thin Solid Films. vol. 377-378, pp. 727 – 732, 2000.
  14. Jun-Sung Kim, Nam-Goo Cha, Kang Kug Lee, Jin-Goo Park, Hyung-Jae Shin. Characterization of fluorocarbon thin films by AFM/LFM and contact angle measurements. Journal of the Microelectronics and Packaging Society. vol. 7, No. 1, pp. 35 – 40, 2000.
  15. Jin-Goo Park, Myong-Jong Kwon, Kang Kug Lee, Yong-Kweon Kim, Hyung-Jae Shin. The vapor phase deposition of fluorocarbon films for the prevention of in-use stiction in micromirror. Jpn. J. Appl. Phys. vol. 37, No. 12B, pp. 7058 – 7063, 1998.

Referred Conference Proceedings

  1. Kang Kug Lee and Christian I. Hong. Ultra low cost blood diagnostic chip for point-of-care clinical detection. Hilton Head Workshop 2016: A Solid-State Sensors, Actuators, and Microsystems Workshop, June 5 – 9, 2016, Hilton Head Island, SC, USA, pp. 288 – 289.
  2. Kang Kug Lee (Corresponding author) and Chong H. Ahn. A whole blood sample-to-answer lab-on-a-chip with asymmetric capillary force based blood plasma separator. Hilton Head Workshop 2014: A Solid-State Sensors, Actuators, and Microsystems Workshop, June 8 – 12, 2014, Hilton Head Island, SC, USA, pp. 167 – 170.
  3. Kang Kug Lee, Chong H. Ahn, Christian I. Hong. Circadian rhythms in neurospora crassa on a microfluidic device for real-time gas perturbations. The 17 th International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers 2013 & Eurosensors XXVII), June 16 – 20, 2013, Barcelona, Spain, pp. 1247 – 1250.
  4. Kang Kug Lee (Corresponding author) and Chong H. Ahn. A new asymmetric capillary force driven whole blood/plasma separator using spray layer-by-layer nano-assembly. The 16 th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2012), Oct. 28 – Nov. 1, 2012, Okinawa, Japan, pp. 1936 – 1938.
  5. Kang Kug Lee (Corresponding author) and Chong H. Ahn. Nanoporous-based hydrophilic polymer microchannel using a spray layer-by-layer electrostatic nano-assembly. Hilton Head Workshop 2012: Solid-State Sensors, Actuators, and Microsystems Workshop, June 3 – 7, 2012, Hilton Head Island, SC, USA, pp. 209 – 212.
  6. Kang Kug Lee, Am Jang, Michael J. Rust, Paul L. Bishop, Chong H. Ahn. Self-assembly nanobead-packed hetero columns for ph and nitrate ion-selective sensors. The 13 th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2009), November 1 – 5, 2009, Jeju Island, Korea, pp. 1632 – 1634.
  7. Andrew W. Browne, WooSeok Jung, Kang Kug Lee, SeHwan Lee, Jaephil Do, Chong H. Ahn. Rapid point of care (poc) blood analysis using integrated dynamic blood separation and sandwich immunoassay on a polymer lab chip. The 12 th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2008), October 12 – 16, 2008, San Diego, CA, USA, pp. 417 – 419.
  8. Kang Kug Lee, Nam-Goo Cha, Joon-Sung Kim, Jin-Goo Park, Hyung-Jae Shin. Chemical, optical and tribological characterization of perfluoropolymer films as an anti-sticking layer in micro-mirror arrays. International Conference on Metallurgical Coatings and Thin Films, April 10 – 14, 2000, San Diego, CA, USA.
  9. Nam-Goo Cha, Joon-Sung Kim, Kang Kug Lee, Jin-Goo Park, Hyung-Jae Shin. Atomic/lateral force microscopy measurements of anti-sticking layer in micro-electro-mechanical systems (MEMS). The 2 nd Korean MEMS Conference, April 14 – 15, 2000, KAIST, Korea.
  10. Kang Kug Lee, Jin-Goo Park, Hyung-Jae Shin. The characterization of optical properties of fluorocarbon polymer thin films on silicon substrate by a variable angle spectroscopic ellipsometry. Materials Research Society Symposium, Fall Meeting, November 29 – December 3, 1999, Boston, MA, USA, vol. 588, pp. 297 – 302.
  11. Dae-Hong Eum, Sang-Yong Kim, Kang Kug Lee, Ki-Sub Kim, Hyung-Soo Song, Jin-Goo Park. The reaction of H 2O 2 and ozone in ammonium hydroxide (NH 4 OH) solutions with silicon wafers. The 1999 Joint International Meeting of the Electrochemical Society, October 17 – 22, 1999, Honolulu, Hawaii, USA, vol. 99 – 36, pp. 288 – 295.
  12. Kang Kug Lee, Jin-Goo Park, Yong-Kweon Kim, Hyung-Jae Shin. Optical properties of fluorocarbon thin films on aluminum top layers in micro-mirror arrays. The 1 st Korean MEMS Conference, April 17, 1999, KAIST, Korea.

Presentations

  1. Kang Kug Lee and Chong H. Ahn. A sample-to-answer lab-on-a-chip integrated with on-chip blood/plasma separator. Center for Advanced Design and Manufacturing of Integrated Microfluidics (CADMIM) Planning Meeting, University of California, Irvine, April 10 – 11, 2014, Irvine, CA, USA.
  2. Am Jang, Kang Kug Lee, Se Hwan Lee, Chong H. Ahn, and Paul L. Bishop. Development of disposable microfabricated chip sensor using nano bead packing method to measure ORP. International Environmental Nanotechnology Conference: Applications and Implications, October 7 – 9, 2008, Chicago, IL, USA.
  3. Kang Kug Lee, Bharat Bhushan, Derek Hansford. Nanotribological characterization of perfluoropolymer thin films for BioMEMS applications. NLIM Annual Review, The Ohio State University, September 20 – 21, 2004, Columbus, OH, USA.
  4. Joon-Sung Kim, Nam-Goo Cha, Kang Kug Lee, Jin-Goo Park. Characterization of perfluoropolymer thin films grown by pulsed PECVD. Material Research Society of Korea, Spring Meeting, May 19 – 20, 2000, Jeonnam University, Korea.
  5. Nam-Goo Cha, Kang Kug Lee, Jin-Goo Park, Hyung-Jae Shin. Characterization of perfluoropolymer thin films on TEOS deposited by thermal evaporation. The International Microelectronics and Packaging Society of Korea, Fall Meeting, November 12, 1999, Hanyang University, Korea.
  6. Nam-Goo Cha, Kang Kug Lee, Jin-Goo Park, Hyung-Jae Shin. The deposition of fluorinated thin films by thermal evaporation and PECVD. Material Research Society of Korea, Fall Meeting, November 5, 1999, Inha University, Korea.
  7. Kang Kug Lee and Jin-Goo Park. Optical modeling of fluorocarbon polymer thin films on silicon substrate. Material Research Society of Korea, Spring Meeting, May 14 – 15, 1999, KumHo University, Korea.
  8. Nam-Goo Cha, Kang Kug Lee, Jin-Goo Park. Characterization of fluorocarbon thin films by contact angle measurements. Material Research Society of Korea, Spring Meeting, May 14 – 15, 1999, KumHo University, Korea.
  9. Myong-Jong Kwon, Kang Kug Lee, Jin-Goo Park. The vapor phase deposition of fluorocarbon organic thin films and its characterization. The International Microelectronics and Packaging Society of Korea, Fall Meeting, November 14, 1998, Hanyang University, Korea.
  10. Kang Kug Lee, Myoung-Jong Kwon, Jin-Goo Park. Determination of thickness and optical properties of fc thin film on al by a variable angle spectroscopic ellipsometry. Material Research Society of Korea, Fall Meeting, November 6, 1998, Kuk-Min University, Korea.